Blood-brain barrier and neurological diseases
نویسندگان
چکیده
منابع مشابه
Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases
More than a century ago, Paul Ehrlich demonstrated in a set of dye experiments the lack of permeability of intracerebral vessels to albumin-binding dyes and therefore postulated a barrier between blood and neuronal tissue. Indeed, transport across the blood-brain barrier (BBB) is tightly regulated by at least four different cells that comprise the brain microvascu-lature: the endothelial cell a...
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Background and purpose: Allicin has a wide range of pharmacological functions, all of which can be demonstrated in anti-inflammatory, antioxidant, antifungal and anti-tumor activities. In this research, we investigated the neuroprotective role of allicin in the process of diffuse traumatic brain injury and its effect on interleukin levels and histological changes in rats. Materials and method...
متن کاملEffect of Nesfatin-1 on Permeability of Blood Brain Barrier, Neurological Score and Brain Edema after Traumatic Brain Injury in Male Rats: A Behavioral and Biochemical Study
Background and purpose: Traumatic brain injury (TBI) is one of the most complex diseases of the central nervous system (CNS). Nesfatin is an 82-amino acid effective polypeptide in CNS. In this study, we investigated the role of nesfatin in neuron protection in the process of diffuse concussion in rats and also its effect on the level of matrix metalloproteinase-9. Materials and methods: In thi...
متن کاملThe blood-brain barrier in neuroinflammatory diseases.
I. The blood-brain barrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 A. Morphology and function. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 B. Mechanisms of transport of compounds across the blood-brain barrier . . . . ....
متن کاملThe Blood-Brain Barrier Challenge for the Treatment of Brain Cancer, Secondary Brain Metastases, and Neurological Diseases.
Formation of metastases from various tumor entities in the brain is a major problem for the treatment of advanced cancer. We describe target molecules and tools for the delivery of small molecules or proteins across the blood-brain barrier (BBB), and the treatment of brain tumors and metastases with antibody-related moieties. In addition, drugs preventing formation of metastases or interfering ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Neuroimmunology
سال: 2015
ISSN: 1759-1961
DOI: 10.1111/cen3.12229